PDA TR 87

This technical report focuses on a technical understanding of glass, its strength, and its limitations, and provides guidance in best handling practices for glass vials throughout the pharmaceutical process -- receipt, storage, preparation, filling, stoppering, freeze-drying, and capping. This document focuses on where surface damage may occur and where excess stresses may be applied during processing and handling.

This report also reviews typical pharmaceutical glass handling processes and identifies areas of concern. Points to consider are presented for line, material, and equipment enhancements as well as guidance and practical approaches for using procedural controls to better employ existing equipment.